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Rapid weight loss has been associated with gallbladder-related disorders including cholelithiasis and cholecystitis [67, 68], and these adverse events, while rare, have been observed more with GLP-1RAs compared with placebo in clinical trials [21, 38]
It's a reflection of the fact that no one has funded the studies required to detect those signals
doi:10.1155/2024/8056440 Berg S, Stickle H, Rose SJ, Nemec EC
(A) Aggregated results of 49 murine scRNAseq datasets showing expression of genes for canonical melatonin receptors, melatonin synthesis, and the NRF2-Glutathione pathway
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