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7 On the one hand, they showed a good correlation between the H3K27me3 expression pattern (C36B11 immunostaining) and the PRC2 component genotype (EED and/or SUZ12) and, on the other hand, tested a new monoclonal H3K27me3 antibody (clone C36B11), which demonstrated a better signal-to-noise ratio with a crisper appearance and less background staining than that used by Lee et al , 4 that is, polyclonal antibody 07-449