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One way that the water activity of products in the mid and low water activity range can change is due to moisture migration
This effect appeared to be mediated by antioxidant mechanisms involving GSK3 phosphorylation 156 , and it was also associated with a reduction of measures of memory impairment in mice 157
The math gets tight quickly, which is exactly the problem Rachel ran into
We can't stress this enough: the storage guidelines for an unopened vial and an opened vial are completely different
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