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Compounded drugs are not FDA-approved, meaning that the safety and quality of these products are not regulated by the FDA, said Stacy Marshall, M.D., a medical toxicologist at the Alabama Poison Information Center and a researcher involved in the UAB-led study

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These include increased growth hormone release, modulation of IGF-1 expression, and activation of downstream pathways related to protein synthesis and energy metabolism

This is one reason it has generated so much attention in obesity medicine: it goes beyond the mechanisms used by single-pathway or dual-pathway therapies and aims to influence appetite, glycemic control, and energy balance through multiple metabolic signals