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IGF-1 activates the PI3K/Akt/mTOR pathway in muscle cells, stimulating protein synthesis, nitrogen retention, and hypertrophy

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Signaling via pancreatic -cells underlies the insulinotropic effects of GLP-1 RAs, while activation of enteric GLP-1Rs delays gastric emptying, effectively blunting postprandial glucose spikes and prolonging satiety (Kreymann et al., 1987