Several reports are indicating that plant polyphenols, including HT, curcumin, and resveratrol, can regulate mitophagy to eliminate damaged mitochondria and maintain the intracellular redox balance, thereby improving related diseases [19, 62, 63]
[13] [15] While the evidence is largely based on case reports and physiological rationale rather than large controlled studies, this has led to increased awareness and the development of specific management strategies
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An AI-powered approach could elevate this strategy by designing a hydrogel matrix capable of achieving a zero-order, non-fluctuating release of dopamine, better mimicking natural physiological levels and potentially reducing the side effects associated with pulsed L-DOPA administration