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Pregnant or breastfeeding women, due to insufficient safety data for berberine

Rapamycin addresses cellular senescence in the follicle microenvironment by inhibiting mTOR, while GHK-Cu works on Wnt signaling, inflammation, and androgen receptor sensitivity

Interestingly, GI adverse events and GLP-1 RA discontinuations were more common in participants not treated with metformin, which may represent increased susceptibility of this group to gut-related adverse events, resulting in intolerance to metformin previously as well as to GLP-1 RAs in the trials

Also, be careful about giving supplements to a child, unless recommended by their healthcare provider.