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It not only provides the material and energetic basis for the unlimited proliferation of tumor cells, but also reshapes the tumor immune microenvironment (TIME) by regulating metabolite levels (including lactate, glutamate, serine, etc.) and mediating epigenetic modifications such as histone lactylation and methylation

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In the cytosol, mtDNA activates cyclic GMPAMP synthasestimulator of interferon genes pathway(the cGAS-STING pathway) to induce type I interferons and enhance NF-B signaling ( 2.1.1.2 N-formyl peptides These are short peptides originating from mitochondrial proteins that still initiate with N-formyl-methionine (a signature of bacteria and mitochondria)