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Despite the fact that both GIP and GLP-1 levels depend on renal metabolism, and are increased in individuals with CKD and renal failure [45, 46], no relevant effects of eGFR on drug exposure were detected when assessing the pharmacokinetics of tirzepatide 5 mg in individuals with preserved renal function or various degrees of renal impairment [47]
158,159 Furthermore, activation of GLP-1R in skeletal muscle cells enhances autophagic activity and promotes the generation of new mitochondria, which helps prevent the accumulation of SCs and improves cellular maintenance
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