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While targeting extracellular collagen processing through LOX/LOXL inhibition has the potential to attenuate postischemic fibrosis, 232 clinical trials of LOXL2-blocking simtuzumab have proven ineffective due to enzymatic redundancy
El-Hattab, AW, Adesina, AM, Jones, J, Scaglia, F 2015, MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options, Molecular genetics and metabolism , vol
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Additionally, each incremental increase in legume consumption was associated with an 8% reduction in DKD risk (HR = 0.92, 95% CI: 0.841.01)
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