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Skin may feel firmer to the touch, fine lines may appear softer, and overall skin quality often improves

This mechanism is particularly beneficial in conditions characterized by excessive or thickened mucus, [35] such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, rhinitis or sinusitis

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A meta-analysis of seven SURPASS clinical trials in participants with T2DM showed the hazard ratios comparing tirzepatide versus controls of 0.80 (95% CI, 0.57 1.11) for 4-MACE, 0.90 (95% CI, 0.50 1.61) for cardiovascular death, and 0.80 (95% CI, 0.51 1.25) for all-cause mortality (264)