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CNS actions GLP-1R signaling plays a critical role in the maintenance of glucose homeostasis as deletion of the GLP-1R in mice results in impaired glucose tolerance (Scrocchi et al., In addition to this direct control of beta cells, GLP-1R signaling plays a role in the control of glucose homeostasis by regulating the activity of neurons both in the peripheral and central nervous system

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Drug Discovery Today, 20(1), 122-128

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