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[2] [5] The pharmacological rationale behind this triple agonism is to engage complementary metabolic pathways simultaneously

Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial

Tirzepatide's dual-action approach Tirzepatide (found in Mounjaro and Zepbound) works differently by activating not one, but two hormone receptors: GLP-1 receptors (the same ones that semaglutide targets) GIP (glucose-dependent insulinotropic polypeptide) receptors This dual-action approach creates complementary effects on hunger, metabolism, and blood sugar regulation and yielding more impactful results than GLP-1 alone

Yes regular physical activity is strongly recommended