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Patients with heart failure with reduced ejection fraction experienced a 35% reduction in major cardiovascular events (hazard ratio 0.65, 95% CI 0.49-0.87), while those with heart failure with preserved ejection fraction saw a 31% reduction (hazard ratio 0.69, 95% CI 0.51-0.91)

A 2D projection was performed for the Gibbs free energy landscape on the plane formed by each simulations first two essential eigenvectors with the apo and holo structures

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