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PloS Pathog
This dampening of the HPA stress response occurs without suppressing normal cortisol rhythms, suggesting that DSIP acts as a modulator rather than an inhibitor of stress signalling
Therefore, to accurately assess the safety and efficacy of topical collagen peptidesparticularly those employing enhanced delivery systemswell-designed, randomized, double-blind, controlled clinical trials in humans are still required
Gout can process through four pathophysiological stages: hyperuricemia without MSU crystal deposition, MSU crystals without signs of gout, acute gout flares, advanced gout, therefore, this study will be more systematic when a reasonable amount of patients at interval stage of gout are recruited
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