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A patient who loses only 2-3% of their body weight may still experience the full cardiovascular benefit of the medication

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It also affects delaying gastric emptying, slowing the absorption of nutrients, but also causing feelings of fullness, bloating, and nausea [35, 36]

Carnitine acetyltransferase (CrAT) can act as safety valve to catalyze the reversible transfer of acetyl groups between acetyl-CoA and acetylcarnitine, promoting the combination of excess acyl groups with carnitine, increasing the membrane permeability of these products and thus removing them from the mitochondria, allowing acylcarnitine to be formed in the mitochondrial matrix and exported to the plasma [7]