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According to a small-scale 2018 study, oral semaglutide does not affect the bioavailability of the combined birth control pill, which contains ethinylestradiol and levonorgestrel
On 29 January 2026, the MHRA updated product information for GLP-1s and issued a drug safety alert to highlight that acute pancreatitis is a known but infrequent side effect that can be fatal, stressing that patients and clinicians should be alert to initial symptoms, such as severe, persistent stomach pain that may radiate to the back and may be accompanied by nausea and vomiting 26
These usually improve over time, but simple strategies can make them easier to manage
Intranasal administration provides faster onset for acute use
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