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For many patients, the clinical benefits of GLP-1sparticularly sustained weight loss and metabolic improvementsare closely tied to continued use.[166] Once treatment is discontinued, individuals often experience weight regain and the return of obesity-related health conditions, underscoring the need to view obesity as a chronic condition that may require long-term treatment.[167] Adherence is also influenced by treatment tolerability.[168] While GLP-1s are generally well tolerated, side effects such as gastrointestinal symptoms and the inconvenience of regular self-injections may deter adherence for certain patients.[169] Recognizing the challenges associated with long-term adherence, pharmaceutical companies are innovating through the development of more-convenient delivery methods

Within 28 weeks of quitting semaglutide, more than 40% of the weight lost in the STEP-10 study was recovered

Reconstitution Materials The bacteriostatic water or saline used for reconstitution matters too