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This gives it a half-life long enough to support once-weekly dosing, a major practical advantage over earlier amylin-based therapies like pramlintide, which required multiple daily injections
They do this by slowing down the activity of bacterial cells, keeping them in a phase where they no longer multiply
Observe 4-8 weeks off-cycle monitoring whether improvements sustained or regression occurs
10.1093/ibd/izz328 118
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