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The study examined safety parameters and metabolic biomarkers over a 12-week treatment period [2]

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When Tramadol May Be Appropriate: If your doctor determines tramadol is necessary for moderate pain, they may: Start with the lowest effective dose Monitor closely for gastrointestinal side effects Provide anti-emetic medication if needed Schedule regular reviews to assess ongoing necessity Consider modified-release formulations to minimise peak-related side effects Alternative Approaches: Depending on your pain condition, non-pharmacological strategies may complement or reduce medication needs: Physical therapy and exercise programmes Cognitive behavioural therapy (CBT) for chronic pain Topical treatments (NSAIDs gels, capsaicin cream) for localised pain TENS machines for certain pain types When to Seek Medical Advice: Contact your GP or healthcare provider if you experience: Severe or persistent nausea and vomiting preventing adequate nutrition or hydration Severe abdominal pain, particularly if accompanied by vomiting Signs of pancreatitis (severe, persistent upper abdominal pain vomiting)stop semaglutide and seek urgent medical assessment Inadequate pain control with current medication Side effects affecting your quality of life or medication adherence NICE guidance (NG193) emphasises individualised pain management and regular medication reviews

Led by our PhD student Aksayan Arunanthy Mahalingasivam, this study highlights that while GLP-1 RAs are established for glycaemic control, weight loss, and cardiovascular protection Their role in bone health remains less clear and needs further research Read the article here: #Diabetes #BoneHealth #FractureRisk #GLP1RA #CardiovascularOutcomes #StenoDiabetes #EndoNorth To view or add a comment, sign in Today, more than 1 billion people live with obesity, a condition closely linked to cardiometabolic diseases such as type 2 diabetes and cardiovascular disease