3rd week on semaglutide 6 weeks in : r/Semaglutide What to Expect with Semaglutide

Dosing Protocol Suggested weekly titration approach from clinical trials

In addition, the magnitude of the 1-year mortality reduction observed in GLP-1 RA userslarger than in randomized trialssuggests that residual confounding may persist, including confounding by indication/clinical channeling and a healthy-user effect, and that estimates may be comparator-dependent

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This improvement occurs through multiple mechanisms: reduced aromatase activity as fat mass decreases, improved insulin sensitivity, decreased inflammatory cytokines, and restoration of normal hypothalamic-pituitary function