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Macrophages can polarize into two distinct phenotypes: M1, which exhibits pro-inflammatory properties, and M2, which is associated with anti-inflammatory functions (Zhang et al., 2023
Essential elements include HPLC (High Performance Liquid Chromatography) purity testing showing 98% or higher purity, mass spectrometry confirming correct molecular identity, and endotoxin testing ensuring bacterial contamination remains within safe limits
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Whereas it is unlikely that the topical preparation as such immediately and directly reaches the hair bulb region, it has been shown that drug delivery to the skin occurs also through the hair follicles [32]
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