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211 Hyperactivation commonly arises from mutations in PIK3CA (detected in ~35-40% of ER + /HER2 cases), AKT1 mutations, or PTEN loss

In addition, it remains very uncertain whether gut microbiome is a causative factor or a consequence of the disease, which necessitates more thoughtful approaches, including colonization of germ-free mice with gut microbiome associated with the disease which might offer more insight into the role of these bacteria in the disease pathogenesis

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Energy Nutrients : if you cannot get up out of bed in the morning, consider 1/2 to 1 serving taken while still in bed (best taken immediately upon waking while still laying down)