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Semaglutide , the active ingredient in our GLP-1 medications, is a GLP-1 receptor agonist that mimics the natural glucagon-like peptide-1 hormone your body produces after eating

Cannot increase to a higher dose Sometimes, people do not feel as much appetite reduction with semaglutide because they are not able to increase to a higher dose, or they may not tolerate higher doses due to side effects like nausea or stomach upset, says Karalis, RD

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Similar reductions in serum LH were reported with GLP-1/GIP administration, while GLP-1/E treatment restored estrous cyclicity and increased the number of corpora lutea across multiple generations (Sanchez-Garrido et al., 2024)