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In all these various methods, it is basically difficult to have a good synthesis effect by using a linear coupling method, mainly the polypeptide sequence structure of semaglutide itself, the N-terminal fragment: H-His 1 -Aib 2 -Glu 3 -Gly 4 -Thr 5 -Phe 6 -Thr 7 -Ser 8 -Asp 9 -Val 10 -Ser 11 -Ser 12 -Tyr 13 -Leu 14 Because of strong hydrophobicity, a secondary structure such as beta-sheet is easily formed, coupling is very difficult, and condensation efficiency is very low

L-carnitine supplementation in childhood epilepsy: current perspectives [PMID: 9821988] Laboratory literature summary: L-carnitine supplementation in childhood epilepsy: current perspectives

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