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Microarray-style gene expression work referenced in the literature reported shifts across several hundred genes following copper-peptide exposure, spanning categories tied to protein synthesis, cell signaling, and antioxidant defense
In a Phase 2 trial involving people with biopsy-confirmed MASH and liver fibrosis, improvement in MASH without worsening of fibrosis occurred in up to 62% of participants receiving survodutide, compared with 14% receiving placebo
Research indicates that certain serotonergic antidepressants, such as fluoxetine, can decrease blood glucose levels, enhance glucose regulation, and improve insulin sensitivity [163]
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