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non-enzymatic actions and the overall significance of DPP-4 for normal physiological regulation in humans and for the pathogenesis of metabolic disease are still largely unknown, targeting the catalytic activity has been harnessed pharmacologically, and DPP-4 inhibitors now play an important part in the therapy of T2DM
Tirzepatide has established proof-of-concept for the GIP/GLP-1 receptor agonist mechanism of action, but the pipeline extends further
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DOI: 10.1210/endrev/bnad019 Imai S & Guarente L (2014) Trends in Cell Biology , 24(8): 464471 (npj Aging) Foundational review confirming the intimate connection between NAD+ availability and sirtuin activity as a conserved ageing/longevity regulatory axis
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