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Acknowledgments The authors would like to thank Aouatef Bellamine, for her help with study management and Suzanne Morris, at Concrete Medical Writing, LLC, for providing medical writing support (funded by Lonza)
These genetic defects were accompanied by significantly reduced mitochondrial membrane potential (MMP) and elevated intracellular ROS levels in PCOS-derived ESCs compared to controls [10], confirming that systemic OS translates directly into organelle dysfunction within the endometrial compartment [39]
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After querying all available data sources, including direct contact with principal investigators or corresponding authors, the team found that 27 of the trials had recorded risk of adverse psychiatric outcomes
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