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One of her patients, a man weighing more than 160 kilograms (over 350 pounds) with a history of diabetes who had failed multiple previous attempts to lose weight, was able to lose 35 kilos (77 pounds) more than 20 percent of his body weight with weekly injections of the drug, along with dietary education and a tailored physical activity plan

BartelsEMFolmerVNBliddalHAltmanRDJuhlCTarpSet al

Dosing typically starts at 0.25 mg weekly for diabetes management, with gradual escalation to maintenance doses of 0.5 mg, 1 mg, or 2 mg depending on glycemic control and tolerability

Effects of Semaglutide on Chronic Kidney Disease in Patients With Type 2 Diabetes