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The mechanism of action that makes tirzepatide effective for glycemic control and weight loss also contributes to its gastrointestinal side effect profile
All the authors have read and agreed to the published version of the manuscript
Intended for compound characterization, reference experiments, or laboratory training applications
Our in silico analysis suggested that both compounds occupy the same pocket at the STX7Munc13-4 interface but only ENDO12 is predicted to form a hydrogen bond (2.07 ) between its hydroxyl hydrogen and the side chain of S137 in the disordered region of STX7 that binds Munc13-4
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