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The 2.4 mg dose, which became the standard dose carried forward into phase 3 trials, produced approximately 8% to 9% weight loss in 26 weeks
Semaglutide mimics glucagon-like peptide-1 (GLP-1), a gut hormone that slows gastric emptying, amplifies glucose-dependent insulin release, and acts on hypothalamic appetite centers to reduce hunger and food-seeking
Taking your oral dose 30 minutes before your largest meal of the daytypically lunch or dinnerpositions the medication's peak appetite-suppressing effect during the meal when you need it most
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