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mTORC1 complex alters anabolic and mitochondrial metabolism through transcriptional, translational and post- translational mechanisms: proteins synthesis is stimulated by phosphorylating 4E-BP1 and p70S6 kinase, and the synthesis of lipids through SREBP2 (88, 89)

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Importantly, no increased risks for falls, selected osmotic symptoms or lower limb amputation were observed