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Each works via different pathways, so there could be a benefit

Herbal remedies: Adaptogenic herbs including ashwagandha and rhodiola can help to modulate the bodys stress response and promote a calm, balanced state in those whose systems are overactive

Nevertheless, the involvement of an hypomethylation cannot be ruled out, because in vitro studies suggest that a low concentration of homocysteine specifically inhibits endothelial cell regeneration and directly activates quiescent vascular smooth muscle cells through a mechanism involving decreased carboxymethylation of p21 ras (Lee and Wang, 1999

The best method really depends on your specific needs