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However, under normal physiological conditions, these alternative mechanisms of regulating cell death largely remain unknown ( However, there are still gaps in our understanding of the triggering, execution, and propagation mechanisms of ferroptosis in kidney diseases that require further research

In the initial stage of tissue repair, GHK released by SPARC and other peptides containing GHK sequences (such as KGHK) during proteolysis stimulate the growth of new blood vessels

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Muller TD, Clemmensen C, Finan B, DiMarchi RD, Tschop MH