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[1] Various mechanisms for the hypopigmentary effect of glutathione have been proposed, with inhibition of tyrosinase being the most important [Box 2]

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Other potential adverse effects of high dose and long-term glutathione supplementation include: Lightening of hair colour: A logically expected effect since hair colour is dependent on the amount and type of melanin which may be altered by glutathione supplementation

Ishihara, et al., Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures