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Notably, GLP-1 RAs have been shown to modulate immune activity by enhancing NK cell cytotoxicity

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The median duration on the second GLP-1RA therapy before switching to a third therapy was highest for tirzepatide (5%) at 10.3 months, followed by dulaglutide (32.5%) at 9.4, semaglutide (28%) at 6, liraglutide (32.5%) at 5.6, and exenatide (2%) at 2 months