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Studies show combination therapy produces greater HbA1c reductions and weight loss than either agent alone in many patients
The fundamentals matter regardless of medication: Calorie deficit through proper nutrition High protein intake (0.7-1g per pound daily minimum) Resistance training 2-4x weekly Adequate sleep and stress management Sustainable lifestyle changes Medications like retatrutide can be powerful tools, but they work best when combined with the basics
Chetty AK et al
GLP-1 and Tirzepatide injections are generally not painful, but individual experiences may vary
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