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At these doses, weight loss was present but typically less than what was seen with the high-dose injections
Although a small observational pilot study on 15 diabetic patients with biopsy-proven NAFLD demonstrated biochemical and histological improvement after a 1-year course of sitagliptin [89] further RCTs failed to demonstrate any beneficial effect of sitagliptin on NAFLD in diabetic patients
The pivotal SURMOUNT-1 trial that established tirzepatide's weight-loss efficacy capped doses at 5, 10, and 15 mg weekly and showed 20.9% mean body-weight reduction at 15 mg over 72 weeks (Jastreboff et al., 2022)
The reality is that the current guidelines allow for drugs to be compounded in exceptional circumstances
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