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All members of the NLR family possess three conserved structural domains that determine their functional mechanisms: (1) The Nterminal effector domain (e.g., CARD, PYD, or BIR domains) mediates interactions with adaptor proteins and downstream signaling effectors, acting as the primary transducer of receptor activation signals

Its clinical development was halted after Phase 2b trials

These reactions are catalyzed by transferase enzymes such as glutathione S- transferases

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