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While off-label prescribing is legally permissible in the US, it should be approached with caution, informed consent, and appropriate monitoring when considering these medications for patients with problematic alcohol use
Proper injection technique, site rotation, and allowing alcohol to dry completely before injecting minimize these reactions
Zepbound shows slightly lower rates of nausea (25% vs 28%) and vomiting (15% vs 17%) compared to Retatrutide
Some clinicians overlap the medications briefly during the transition, continuing phentermine while semaglutide titrates up, then discontinuing phentermine once semaglutide reaches therapeutic levels
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