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Disorders of the thyroid or hormones that have not been successfully treated by other means
Treatment combined with antioxidant and anti-fibrotic drugs to intervene in patients can delay the disease process to a certain extent [14]
Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
In a similar study with bull sperm, Barbato et al
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