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In 3Tg-AD treated with DA-JC4, the ability of recognize new object and spatial working memory was improved, hippocampal A and tau pathology were alleviated, and hippocampal synaptic plasticity also was improved as well as levels of PSD95 and SYP were increased (235)
Additionally, Biotin is believed to have anti-inflammatory effects, improve cognitive function, raise HDL (good) cholesterol and lower LDL (bad) cholesterol.
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Considering that PSC activation is a key factor in pancreatic fibrosis, we speculated that excess ROS production induced by high glucose may induce PSC activation in vivo
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