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Larazotide , also known as Larazotide acetate (LA), is a synthetic peptide that is made up of a single-chain peptide of eight amino acids that acts as a tight junction regulator to restore intestinal barrier function (Slifer et al., 2021)
It does this by inactivating it
Its biological output is dynamically tuned by therapeutic modality, microenvironmental redox conditions, post-transcriptional regulation (e.g., miR-23a-3p and miR-145-5p), post-translational modification (e.g., SIAH2-mediated ubiquitination), and substrate flux partitioning
PMID: 39 ZhuYFujimakiMSnapeLLopezAFlemingARubinszteinDC
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