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Bitter Orange Extract Bitter orange extract is found in some citrus fruits and contains synephrine, a stimulant with effects similar to ephedrine (a dangerous ingredient banned by the FDA for use in diet and sports supplements because it showed to have serious health risks like heart attack and stroke, resulting in deaths), according to a 2022 review of the safety and efficacy of bitter orange extract in Nutrients

Researchers found that participants taking Calocurb, a dietary supplement formulated with a New Zealand hops extract called Amarasate, lost an average of 8.3 pounds over 24 weeks while maintaining lean muscle mass

After 68 weeks, half of the participants using semaglutide lost 15% of their body weight, and nearly a third lost 20%

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