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They already take enough medication
The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary
The most important current difference is regulatory: Wegovy is licensed to reduce cardiovascular risk, whereas tirzepatides cardiovascular licence is still being assessed
3.6 Metformin The principal treatment for diabetes mellitus type 2 is metformin, which is still recommended in all guidelines unless it is contraindicated
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