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In CRPC, AR signaling upregulates inhibitory immune checkpoints (e.g., B7-H3) and proinflammatory cytokines (e.g., IL-6, TNF-), which recruit immunosuppressive cells and suppress T-cell function
Four weeks might work for a fresh injury, but it is often too short for chronic, long-term conditions
However, the safest treatment depends on the patient, not the trend
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