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Established therapies such as platelet-rich plasma (PRP) have more extensive clinical evidence and regulatory approval for certain applications

For Indian skin (Fitzpatrick IVVI) Sodium hyaluronate has been shown to support hydration in deeper skin tones where transepidermal water loss may be elevated, particularly relevant in Kerala's humid tropical climate where excessive moisture can paradoxically lead to dehydration due to osmotic stress

Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options

Such targeted approaches could potentially reduce the overall dose required and minimize any potential interference with glutathione synthesis in non-target tissues