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TGF-1 + IL-1 promotes NLRP3 inflammasome activation, glycolysis and histone lactylation in lung fibroblasts Since fibroblasts play a central role in pulmonary fibrosis, primary mouse lung fibroblasts were isolated and cultured for further experiments

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Other common side effects reported in 5% or more of people in clinical trials include: Digestive system Indigestion (dyspepsia) Abdominal pain or upper abdominal pain Gastroenteritis (stomach bug) Increased lipase levels (a pancreatic enzyme, detected on blood tests) General Headache Fatigue (feeling tired) Dizziness Fever Other Injection site reactions such as redness, irritation, or bruising Low blood sugar (hypoglycemia), particularly if you also take insulin or a sulfonylurea Contact your doctor if any side effects are severe, persistent, or affecting your daily life

Recent studies have highlighted the utility of biomarkers, such as NGF and BDNF, in predicting the progression of neuropathy and response to therapy