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Given the secondary nature of this study and the number of statistical tests, we did not look at possible clinical/behavioral implications of these endocrine effects a relevant question that was beyond the scope of the present study and should be explored in the future

Topiramate is available as immediate-release (IR) oral tablets, extended-release (XR) oral capsules, and IR sprinkle capsules that can be opened and mixed into soft foods

Patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should not use these medications

It is best known in research for its activity at the melanocortin-1 receptor (MC1R), and its straight, linear chain is what marks it out among MSH analogs