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Managing Fat Intake to Reduce GI Distress Here's the thing about fat on GLP-1s: you need some (it's essential for hormone production and nutrient absorption), but too much at once can worsen nausea and slow digestion even more

The Human GLP-1 Analogs Liraglutide and Semaglutide: Absence of Histopathological Effects on the Pancreas in Nonhuman Primate

These rates compare favorably with the Phase 2 discontinuation rates (10-17%), likely reflecting the improved dose-escalation schedules used in Phase 3